Dr. Bowdish speaks about the role of the microbiome in inflammation and healthy/unhealthy aging (starting at 26:02). Other speakers include Dr. Luigi Ferrucci from the NIH Institute of Aging and Dr. James Kirkland who speaks about clinical trials testing senolytics.
Congratulations Sara for winning the Gerald T Simons award for her presentation at the Microscopical Society of Canada and Microscopical Society of America (M&M2018) in Baltimore.
To read her award winning abstract, click here.
Congratulations to the newly minted Dr. Loukov on successfully defending her thesis entitled “Age-Associated Inflammation impairs Myeloid Development and Monocyte & Macrophage Function”!
The Bowdish lab was very proud to host Anika Gupta, a high school student, for her Bay Area Science and Engineering Fair (BASEF) project.
Her project was entitled “Quantifying Lung Macrophages to Understand Increased Susceptibility to Bacterial Pneumonia with Age.”
Anita won the Dr. Doyle Biology Award for the best Biology project, a Gold merit award as well as the Pinnacle Award for the Third Best in Fair and a sponsored Trip Award to compete in the Intel International Science and Engineering Fair in Pittsburgh, Pennsylvania in May!
Way to go Anika!
See her featured in the Hamilton news here.…
Dr. Bowdish explains what cooties are, how the microbes that live on and in us can be friends and foes and describes how differences in infections and health between boys and girls, men and women are sometimes due to biology and sometimes due to behaviour.
Read the article summarizing the event here.
To see Dr. Bowdish put on a macrophage cape and teach the school kids the difference between a commensal, a pathobiont and a pathogen by dressing up their teachers, watch here…..
Kyle Novakowski successfully defended his thesis “IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF CONSERVED RESIDUES AND DOMAINS IN THE MACROPHAGE SCAVENGER RECEPTOR MARCO” to become the Bowdish lab’s 4th PhD student. He’ll be joining Turnstone Biologics as a PhD scientist. We wish him very well in his future endeavours. Congratulations Dr. Novakowski!
First author on the publication, PhD student Kyle Novakowski of Dr. Dawn Bowdish’s lab.
A common element that links ancient fish that dwell in the darkest depths of the oceans to land mammals, Neanderthals, and humans is the necessity to defend against pathogens. Hundreds of millions of years of evolution have shaped how our innate immune cells, such as macrophages, detect and destroy microorganisms.
In a new study led by Dr. Dawn Bowdish (in collaboration with Dr. Brian Golding) and her PhD student Kyle Novakowski, the team identified novel sites within a macrophage receptor, MARCO, that are under positive selection and are human-specific. The team demonstrated the importance of these sites by site-directed mutation and showed a reduction in cellular binding and uptake of pathogens. These findings demonstrate how small genetic changes in humans can influence how we defend ourselves against pathogens.
Read the full publication in Oxford University Press.
Human-specific mutations and positively-selected sites in MARCO confer functional changes. Novakowski KE, Yap NVL, Yin C, Sakamoto K, Heit B, Golding GB, Bowdish DME. Mol Biol Evol. 2017 Nov 20. doi: 10.1093/molbev/msx298.
The Bowdish lab is looking for new members to join our team! We currently have an opening for a post-doctoral fellow and a graduate student.
The PDF will project will involve investigating how the upper respiratory tract microbiome changes with age and declining immune function. Applicants must have a strong publication record in the field of immunology, microbiology, systems biology or molecular biology and applicants eligible for PDF funding from http://fhs.mcmaster.ca/mgdfa/ are particularly encouraged to apply (see link for eligibility). Experience in analysis of the microbiome or statistics of large/complex datasets are assets. Please provide a c.v. and a cover letter detailing your interest in the lab that includes contact details for references.
The graduate student position will be studying why aging macrophages are less able to kill bacteria. Applicants interested in beginning studies in January, May or Sept 2018 will be considered. Students aiming to pursue a PhD are preferred but exceptional MSc applicants will be considered. Previous research experience is strongly preferred. Candidates must have relevant courses in molecular/cellular biology, biochemistry, immunology or microbiology. Please include a transcript, a cover letter outlining your previous research experience and a list of references. Foreign students must have a scholarship to be considered.
Come join our strong team!