Dr. Bowdish discusses the lab’s research on microbiota and healthy/unhealthy aging on the Agora Health Podcast

Or listen on

Apple podcasts https://podcasts.apple.com/co/podcast/how-the-microbiome-can-affect-your-overall-health-and/id1712499485?i=1000642050180&l=en-GB

Spotify: https://open.spotify.com/episode/0flH90zGfa5bXAVoy1ZiiF?si=f3680075df4b4a2a

Amazon Music: https://music.amazon.com/podcasts/2e2f7513-9491-40e9-a9dc-a31859560d1d/episodes/fce86aa3-0d05-4245-ab87-08be6b86323b/decoding-healthcare-research-how-the-microbiome-can-affect-your-overall-health-and-its-effects-on-aging-ep-15

Dr. Jessica Breznik talks about her research in the American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

In this podcast first author Dr. Jessica A. Breznik of McMaster University, discusses the recently published manuscript titled “Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor.” 

NEW & NOTEWORTHY We found that diet-induced obesity in female mice has tissue- and time-dependent effects on intestinal paracellular permeability as well as monocyte-derived and tissue-resident macrophage numbers, surface marker phenotype, and intracellular production of the cytokines IL-10 and TNF. These changes were not mediated by TNF.

Article Citation: Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factorJessica A. Breznik, Jennifer Jury, Elena F. Verdú, Deborah M. Sloboda, and Dawn M. E. Bowdish

American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 324:4, G305-G321

Congratulations to Pat Schenck & Jessica Breznik on winning the Farncombe Research in Progress Awards!

Jessica Breznik (co-supervised by Dr. Deborah Sloboda) won the “Best Presentation by a PhD student” while Pat Schenck (co-supervised by Dr. Mike Surette) won runner up!  What a wonderful tribute to their skills in both research and communication – well done!

Publication: Age-associated Inflammation alters the aging trajectory.

This article is written for lay/broad audiences and describes what age-associated inflammation is and why it may be key to healthy/unhealthy aging.

November is Lung Month – what do older adults need to know about pneumonia?

Dr Bowdish is the Canadian Lung Association’s spokesperson for World Pneumonia Day (November 12, 2018). Here she discusses the importance of being vaccinated for pneumonia….

She also speaks to Zoomer Magazine about pneumonia, vaccinations and the aging immune system here…

To get a sense of the other lung research going on in the Bowdish lab, see our Instagram page: house.macrophage

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Publication: Myeloid-Derived Suppressor Cells in Aged Humans

Myeloid-Derived Suppressor Cells in Aged Humans

Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells whose
immunosuppressive activities contribute to cancer and other diseases. MDSCs
appear to increase with age, and this presumably contributes to immunosuppression
and the increased incidence of certain diseases. Why MDSCs increase with
age is not entirely clear. Herein we present evidence that MDSC expansion is due
in part to age-related changes in hematopoiesis, including the acquisition of
mutations that favor myelopoiesis, which are compounded by changes in the
aging microenvironment that favor the production of MDSCs.

Congratulations to Dessi Loukov on successfully defending her PhD!

Congratulations to the newly minted Dr. Loukov on successfully defending her thesis entitled “Age-Associated Inflammation impairs Myeloid Development and Monocyte & Macrophage Function”!

The newly minted Dr. Loukov drinks from the chalice.

Dessi celebrates her thesis defence with one of her mentors Dr. Mark McDermott.

Two doctors.