Dawn will be presenting a talk entitled “Immunosenescent macrophages cannot control Streptococcus pneumoniae colonization” 9:45 am Oct 7th and poster entitled the same at 11-12 Oct 8th. For the rest of the program click here.
The Bowdish lab has received funding from the CIHR (Pilot Projects in Aging) with Dr. Jennie Johnstone to study how macrophage immunosenescence contributes to susceptibility to pneumonia in the elderly. We have also received funding from the Ontario Thoracic Society/Ontario Lung Association for our work on the role of scavenger receptors in mycobacterial infection and funding from the CIHR (Emerging Team: Human Microbiome, with Drs Mike Surette, Jennie Johnstone, Mike Schryvers, & James Kellner) to study the role of commensal bacteria (including close cousins of S. pneumoniae) contribute to upper respiratory tract infections. This is truly an exciting time for the Bowdish lab – stay tuned for some fantastic science!
Would you like to build your career exploring the immunology of aging?
In the Western world the majority (>90%) of deaths due to pneumonia occur in the elderly. Why they are at such high risk is not entirely clear, but presumably immunosenescence (age related changes in the immune system) is a key factor. The high mortality rate is compounded by co-infections, such as influenza infection. This research project involves developing a mouse model of Streptococcus pneumoniae colonization and infection in aged mouse and determining how co-infection with influenza increases the risk of developing pneumonia. This will include a both a basic science component (i.e. deteremining how age-associated changes in immunity contribute to susceptibility to infection) and a translational component (i.e. testing therapeutic interventions).
An immediate post-doctoral opportunity is available for a creative scientist with a strong commitment to excellence and innovation to pursue leading edge research in immunology. Although this is presently only a 1 year position, this may be extended if the applicant obtains fellowship funding. Candidates with experience in virology or mouse models of infection are especially encouraged to apply.
The position is in the Department of Pathology & Molecular Medicine at McMaster University located in the heart of the Golden Horseshoe in southern Ontario. McMaster University has been ranked as one of Canada’s most research intensive universities known for it’s highly collaborative and mentoring atmosphere.