Dr. Bowdish discusses the implication of our Verschoor et al publication “Blood CD33(+)HLA-DR(-) myeloid-derived suppressor cells are increased with age and a history of cancer.” in studies of aging and cancer in the below commentary.
Click image for .pdf.
This is an open access publication so please feel free to use the following image in presentations/publications providing that it is properly referenced.
What is the best way to reduce infectious disease in the elderly? Vaccination! Unfortunately the aging immune system presents a number of challenges for vaccine development. Bowdish lab PhD candidate Mike Dorrington discusses them in this review and presents a case for developing novel vaccines that work within the constraints of the aging immune system.
Media coverage: This paper was picked up by MDLinx. See their coverage here.
Click image for .pdf.
MDSCs (myeloid derived suppressor cells) are a recently discovered and very heterogenous cell type that appear to directly suppress T cell responses and their presence in the tumour or the circulation is an extremely poor prognostic marker.
The Bowdish lab recently dipped our foot into the confusing world of MDSCs because we were curious to know whether their frequency increases with age and if so, could this explain why age is a risk factor for many cancers. They do increase with age and this may explain why some adaptive immune responses decline with age. One thing we were very surprised to find is that individuals who had any history of cancer but were believed to be in remission had higher levels of these cells in circulation. This begs the question – did these people have higher levels and to begin with and is this why they were predisposed to cancer? Or do they still have subclinical tumours that promote the development of MDSCs? Or does the suppressive environment of the cancer microenvironment stay with you for life? More studies (not by us, that was enough) are warranted.
For the .pdf click here
For the supplementary data, click here.
Dawn will be presenting a talk entitled “Immunosenescent macrophages cannot control Streptococcus pneumoniae colonization” 9:45 am Oct 7th and poster entitled the same at 11-12 Oct 8th. For the rest of the program click here.
The Bowdish lab has received funding from the CIHR (Pilot Projects in Aging) with Dr. Jennie Johnstone to study how macrophage immunosenescence contributes to susceptibility to pneumonia in the elderly. We have also received funding from the Ontario Thoracic Society/Ontario Lung Association for our work on the role of scavenger receptors in mycobacterial infection and funding from the CIHR (Emerging Team: Human Microbiome, with Drs Mike Surette, Jennie Johnstone, Mike Schryvers, & James Kellner) to study the role of commensal bacteria (including close cousins of S. pneumoniae) contribute to upper respiratory tract infections. This is truly an exciting time for the Bowdish lab – stay tuned for some fantastic science!
Would you like to build your career exploring the immunology of aging?
In the Western world the majority (>90%) of deaths due to pneumonia occur in the elderly. Why they are at such high risk is not entirely clear, but presumably immunosenescence (age related changes in the immune system) is a key factor. The high mortality rate is compounded by co-infections, such as influenza infection. This research project involves developing a mouse model of Streptococcus pneumoniae colonization and infection in aged mouse and determining how co-infection with influenza increases the risk of developing pneumonia. This will include a both a basic science component (i.e. deteremining how age-associated changes in immunity contribute to susceptibility to infection) and a translational component (i.e. testing therapeutic interventions).
An immediate post-doctoral opportunity is available for a creative scientist with a strong commitment to excellence and innovation to pursue leading edge research in immunology. Although this is presently only a 1 year position, this may be extended if the applicant obtains fellowship funding. Candidates with experience in virology or mouse models of infection are especially encouraged to apply.
The position is in the Department of Pathology & Molecular Medicine at McMaster University located in the heart of the Golden Horseshoe in southern Ontario. McMaster University has been ranked as one of Canada’s most research intensive universities known for it’s highly collaborative and mentoring atmosphere.
Interested candidates should send a CV, cover letter and three references to Dr. Dawn Bowdish (email@example.com, www.bowdish.ca).