Congratulations to Sara Makaremi (PhD candidate) for winning the Gerald T Simon Award for her microscopy!

Congratulations Sara for winning the Gerald T Simons award for her presentation at the Microscopical Society of Canada and Microscopical Society of America (M&M2018) in Baltimore.

To read her award winning abstract, click here.

 

Congratulations to Dessi Loukov on successfully defending her PhD!

Congratulations to the newly minted Dr. Loukov on successfully defending her thesis entitled “Age-Associated Inflammation impairs Myeloid Development and Monocyte & Macrophage Function”!

The newly minted Dr. Loukov drinks from the chalice.

Dessi celebrates her thesis defence with one of her mentors Dr. Mark McDermott.

Two doctors.

Alumnus Update: Melissa Ling, Bowdish lab undergraduate, accepted to Yale University.

Congratulations to Melissa Ling, a former Bowdish lab undergraduate thesis student who was accepted to Yale University’s Masters of Medical Science in the Physician Associate Program. This prestigious program has a 3.6% acceptance rate so we are very proud of her.

Best of luck Melissa!

Pictured here in her Bowdish lab days.

Kyle Novakowski is the Bowdish lab’s newest PhD!

Kyle Novakowski successfully defended his thesis “IDENTIFICATION AND  FUNCTIONAL CHARACTERIZATION OF CONSERVED RESIDUES AND DOMAINS IN THE MACROPHAGE SCAVENGER RECEPTOR MARCO”  to become the Bowdish lab’s 4th PhD student. He’ll be joining Turnstone Biologics as a PhD scientist. We wish him very well in his future endeavours. Congratulations Dr. Novakowski!

Publication: Human-specific mutations and positively-selected sites in MARCO confer functional changes.

First author on the publication, PhD student Kyle Novakowski of Dr. Dawn Bowdish’s lab.
A common element that links ancient fish that dwell in the darkest depths of the oceans to land mammals, Neanderthals, and humans is the necessity to defend against pathogens. Hundreds of millions of years of evolution have shaped how our innate immune cells, such as macrophages, detect and destroy microorganisms.

In a new study led by Dr. Dawn Bowdish (in collaboration with Dr. Brian Golding) and her PhD student Kyle Novakowski, the team identified novel sites within a macrophage receptor, MARCO, that are under positive selection and are human-specific. The team demonstrated the importance of these sites by site-directed mutation and showed a reduction in cellular binding and uptake of pathogens. These findings demonstrate how small genetic changes in humans can influence how we defend ourselves against pathogens.

Read the full publication in Oxford University Press.

Human-specific mutations and positively-selected sites in MARCO confer functional changes. Novakowski KE, Yap NVL, Yin C, Sakamoto K, Heit B, Golding GB, Bowdish DME. Mol Biol Evol. 2017 Nov 20. doi: 10.1093/molbev/msx298.
PMID: 2916561

Bowdish lab joins the circus.

The lab that plays together stays (late nights scienc-ing) together, which is why the Bowdish lab had our annual retreat at Zacada circus school.  Here we got some very sore muscles and discussed our successes and challenges of the past year and what our goals and ambitious are for the following year. Go Team!

Our annual lab retreat for 2017 was at Zacada Circus school where we learned the trapeze, silks and ran up and down this ninja wall!
Top: Kyle, Dhanyi, Melodie, Joseph, Dessi, Grace, Pat, Mohammad
Bottom: Sara, Janine, Helen, Jessica, Dawn, Allison, Christian.

Alumnus update: Former Bowdish lab undergraduate Charles Yin wins prestigious Vanier scholarship for his MD/PhD work!

Charles Yin 2012smCongratulations to former Bowdish lab undergraduate student Charles Yin on his week of accomplishments – publishing his paper on one of his undergraduate projects and winning a prestigious CIHR Vanier Scholarship for his MD/PhD work at UWO.
Congrats Charles!