How do you balance productivity & psychological safety in a lab? by Dr. Bowdish and others.

Cell Systems asks group leaders how they foster mutually reinforcing research productivity and psychological safety in their teams. Dr. Bowdish and others reflect on this question here…

Publication: Age-associated Inflammation alters the aging trajectory.

This article is written for lay/broad audiences and describes what age-associated inflammation is and why it may be key to healthy/unhealthy aging.

White paper: “Paving The Way For Immunization Innovation” with the Lung Association Ontario

Publication: Myeloid-Derived Suppressor Cells in Aged Humans

Myeloid-Derived Suppressor Cells in Aged Humans

Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells whose
immunosuppressive activities contribute to cancer and other diseases. MDSCs
appear to increase with age, and this presumably contributes to immunosuppression
and the increased incidence of certain diseases. Why MDSCs increase with
age is not entirely clear. Herein we present evidence that MDSC expansion is due
in part to age-related changes in hematopoiesis, including the acquisition of
mutations that favor myelopoiesis, which are compounded by changes in the
aging microenvironment that favor the production of MDSCs.

Publication: Monocyte activation is elevated in women with knee-osteoarthritis and associated with inflammation, BMI and pain.

Dr. Dawn Bowdish and her PhD student Dessi Loukov  collaborated with Dr. Monica Maly and Sara Karampatos (Rehabilitation Science) and found that monocytes were more activated and pro-inflammatory in women with osteoarthritis, and that elevated inflammation and body mass index were associated with increased monocyte activation. Further, the team found that women with osteoarthritis and more activated monocytes experienced worse pain than individuals with less activated monocytes. These findings highlight the importance of modulating inflammation and body mass to manage osteoarthritis and open up new avenues for therapeutic research.

Read the full publication in the Osteoarthritis Research Society International (OARSI) Journal

As featured in Eureka Alert: https://www.eurekalert.org/pub_releases/2017-11/mu-rul112717.php