Born in September? This professor has got bad news for you. Spend an hour of edu-tainment touring through the wackiness of early 19th century psychiatry, stealth mid-century reproductive rights activism, the climate/pregnancy connection, and learn why cold & flu season has an outsize impact on mental health. Didn’t think science could be funny? Come check out the only show in this year’s Fringe put on by a PhD scientist – you might laugh, but you’ll definitely learn. Tickets are “Pay What You Can” and available for as little as $4! Suitable for ages 13+ (PG). Content warning: brief mention of suicidality, mentions of mental health, abortion and reproductive sex.
Show times are:
2nd July 5:00pm 4th July 8:15pm 5th July 1:00pm 7th July 4:45pm 8th July 2:30pm 10th July 4:15pm 12th July 10:15pm
Helen Gardiner Phelan Playhouse 79 St George St, Toronto, ON M5S 3L8
For details and tickets: https://fringetoronto.com/fringe/show/perils-being-born-fall
Politically-driven chaos is disrupting U.S. scientific institutions and creating challenges for science in Canada. Science is a global endeavour and collaborations with the U.S. are routine. In this special episode of Quirks & Quarks, we explore what Canadian scientists are doing to preserve their work to assert scientific sovereignty in the face of this unprecedented destabilization.
Canadian climate scientists brace for cuts to climate science infrastructure and data U.S. President Donald Trump’s attacks on climate science are putting our Earth observing systems, in the oceans and in orbit, at risk. Canadian scientists who rely on U.S. led climate data infrastructure worry about losing long-term data that would affect our ability to understand our changing climate. With: Kate Moran, the president and CEO of Ocean Networks Canada and Emeritus Professor of Oceanography at the University of Victoria Debra Wunch, Physicist at the University of Toronto Chris Fletcher, Department of Geography and Environmental Management at the University of Waterloo
U.S. cuts to Great Lakes science and monitoring threaten our shared freshwater resource U.S. budget and staffing cuts are jeopardizing the long-standing collaboration with our southern neighbour to maintain the health of the Great Lakes, our shared resource and the largest freshwater system in the world. With: Jérôme Marty, executive director of the International Association for Great Lakes Research and part-time professor at the University of Ottawa Greg McClinchey, policy and legislative director with the Great Lakes Fishery Commission Michael Wilkie, Biologist at Wilfred Laurier University Brittney Borowiec, research associate in the Wilkie Lab at Wilfred Laurier University Aaron Fisk, Ecologist and Canada Research Chair at the University of Windsor
Unexpected ways U.S. culture war policies are affecting Canadian scientists One of the first things President Trump did after taking office was to sign an executive order eliminating all DEI policies in the federal government. This is having far-reaching consequences for Canadian scientists as they navigate the new reality of our frequent research partner’s hostility against so-called “woke science.” With: Dr. Sofia Ahmed, Clinician scientist, and academic lead for the Women and Children’s Health Research Institute at the University of Alberta Angela Kaida, professor of health sciences and Canada Research Chair at Simon Fraser University in Vancouver Dawn Bowdish, professor of immunology, the executive director of the Firestone Institute for Respiratory Health and Canada Research Chair at McMaster University Kevin Zhao, MD/PhD student in immunology in the Bowdish Lab at McMaster University (starting at 36:10) Jérôme Marty, executive director of the International Association for Great Lakes Research
Canada has a ‘responsibility’ to step up and assert scientific sovereignty A 2023 report on how to strengthen our federal research support system could be our roadmap to more robust scientific sovereignty. The Advisory Panel on the Federal Research Support System made recommendations to the federal government for how we could reform our funding landscape. The intent was to allow us to quickly respond to national research priorities and to make Canada a more enticing research partner in world science. With: Frédéric Bouchard, Dean of the Faculty of Arts and Sciences and professor of philosophy of science at the Université de Montreal. Chair of the Advisory Panel on the Federal Research Support System.
Link to Bluesky “Skeetorial” here and reproduced below without images:
New paper! “Minimal Impact of Prior Common Cold Coronavirus Exposure on Immune Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination or Infection Risk in Older Adults in Congregate Care”. For those of you who follow our #COVID work, read on for the story behind the story. 1/n
Remember reports like this one from the beginning of the pandemic? How could some older adults show such resilience to COVID compared to their peers? Some thought that they might have cross reactive immunity due to exposure to the related ‘seasonal’ or ‘common cold’ coronaviruses. 2/n
https://www.cbc.ca/news/canada/ottawa/102-year-old-woman-recovers-from-covid-19-1.5567189
After all, our @mcmasteru.bsky.social colleagues, Dr. Mark Loeb & team had shown years earlier that seasonal/common cold coronaviruses caused a lots of infections in long-term care and others had investigated whether these might protect kids from COVID…. 3/n
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108481
….while others have shown that can be very deadly in residents of long-term care (reminding us that words matter and calling them ‘common colds’ minimizes risk – common viruses can still make people very sick, but that is rant for another day). So could pre-existing immunity be protective? 4/n
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00018-1/fulltext
Alternatively, maybe older adults got so sick because a life of exposure to these viruses ‘used up’ all the immune cells that could be used to respond to SARS-CoV-2 or COVID vaccines(i.e. ‘immune imprinting’, a phrase I came to hate along with ‘original antigenic sin’ as it was so misused) 5/n
To find out we tested whether antibody levels for the coronaviruses OC43, HL63, and 229E were higher/lower in people whose first COVID infection was an early Omicron variant and found they were not. Therefore it is unlikely these are either protective or problematic 6/n
What about pre-existing anti-coronavirus T cells? We looked at memory CD4+ and CD8+ T cells against the M & N proteins (indicates prev infections) and Spike (vaccine and infections). No evidence that these differed between those who did/did not get an infection (7/n)
What was a correlate of protection? Anti-RBD-IgG & neutralizing antibodies to the ancestral virus (which is all the residents would have been vaccinated to at that point). Unlike others we didn’t find that (serum) IgA was a correlate of protection. 8/n
Pre-existing immunity to common cold coronaviruses didn’t protect against SARS-CoV-2/COVID but might our vaccines and immunity alter immune responses to seasonal coronaviruses? Antibodies to other coronaviruses increased a bit (‘back-boosting’) after COVID infection or vaccination…. 9/n
But I doubt this will have much effect on the prevalence of other coronaviruses who follow a pretty consistent yearly/biennial or big wave/small wave pattern in the Northern hemisphere. We don’t know why but we do know that immunity doesn’t last long so a small boost from COVID infection/vaccination is not likely to make a difference 10/n
https://www.nature.com/articles/s41591-020-1083-1
Caveats: Only measured peoples first infections in the early Omicron era, only older adults living in LTC and retirement homes, vaccines would have been against the ancestral virus – things might be different in other populations/variants/vaccines. 11/n
Huge shout out to Braeden Cowborough for doing all those titres – that’s a lot of plates – and to Dr Jessica Breznik (former @miramcmaster.bsky.social currently @mcmasternexus.bsky.social PDF) for analytic skills. Thanks to the rest of the COVID-in-LTC team @mcmasteriidr.bsky.social
Serosurveillance describes using blood samples to determine what percentage of the population has been exposed to a pathogen or has been vaccinated by measuring the presence or absence of antibodies to the pathogen or vaccination. During the COVID-19 pandemic Dr. Bowdish and team built a network of long-term care homes to measure vaccine responses and infection rates, but this infrastructure could have been used to measure virtually any infection or any antibody response. The Hema-Net community came together February 14-16 to present data and share experiences using serosurveillance and published this report. Unfortunately, no funds were made available to continue Dr. Bowdish’s or others serosurveillance networks.
Missed the first run of ‘The Perils of Being Born in the Fall’ at the 2024 Hamilton Fringe Festival? Fear not, there is a repeat performance as part of the McMaster Institute for Research on Aging’s “Sage Conversations” series (and there’s free popcorn, drinks & parking – what’s not to love!)
What’s the show about? Well if you are born in September, Dr. Dawn Bowdish has got bad news for you.
Tour through the wackiness of early 19th century psychiatry, stealth mid-century reproductive rights activism and the climate/pregnancy connection; in the end you’ll learn why cold & flu season has an outsize impact on mental health.
You might laugh, but you’ll definitely learn.
Reserve a spot by clicking here
https://www.eventbrite.ca/e/sage-conversations-see-a-one-woman-show-featuring-dawn-bowdish-tickets-1016877456847
New publication alert! “Reassuring humoral and cellular immune responses to SARS-CoV-2 vaccination in participants with systemic sclerosis” Read on to learn why we did this study and why it is important. 1/n https://www.sciencedirect.com/science/article/pii/S0165247824001032?via%3Dihub
Systemic Sclerosis(SSc) is a rare autoimmune disorder that causes fibrosis of the organs. Because it is caused an immune system gone awry, patients and their doctors were concerned that their immune systems might not respond to the vaccine and leave them less protected 2/n
Because SSC is an autoimmune condition, people generally take immunosuppressive drugs, which can also lead to lower vaccine responses and higher risk of infection. We investigated whether antibody or T cell responses to vaccination were affected in SSC. 3/n
Good news! People with SSC made the same amount of antibodies to the receptor binding domain of the Spike protein (i.e, the bit of the virus that the virus uses to get into us) after their second, third, and fourth SARS-CoV-2 vaccinations. 4/n
More good news! T cell responses to vaccines are thought to help with severe disease and may offer some cross-variant protection. Following the second, third, and fourth SARS-CoV-2 vaccinations, participants with SSc had T cell responses = those without SSC. 5/n
For the immunology geeks: People living with SSc have elevated levels of serum cytokines associated with T cell differentiation. Could this change Th1/2/17/reg mix posts vaccination? Nope. 6/n
Caveat#1: This is a small study (because a rare disease) and we couldn’t investigate all the different drugs that people are on. For more info on how drugs affect vaccination responses see our other studies 7/n https://acrjournals.onlinelibrary.wiley.com/doi/full/10.1002/acr2.11697
Caveat #2: This is very much a comparison of the quantity of immune responses, not the quality. There could still be qualitative differences in immune responses that we didn’t catch but… 8/n
…even though there is very little data on whether SSC is associated with higher infection risk or poorer outcomes what little exists doesn’t find a massive difference compared to the general population 9/n https://acrjournals.onlinelibrary.wiley.com/doi/full/10.1002/acr.25226
Take home message #1: Participants with SSc mount similar responses to SARS-CoV-2 vaccination as controls who do not have autoimmune conditions. 10/n
Take home message #2: Many ppl with autoimmune conditions are afraid that vaccination is unsafe for them because they know their immune system is a bit wonky. It is not the disease that affects immune responses, rather it’s some, not all, drugs at some, not all, doses. 11/n
Thanks to emerging leader & 1st author Jenna Benoit (graduating & looking for a job next year – hint), rheumatologist extraordinaire, Dr. Maggie Larche, cellular immunologist Dr. J. Breznik & J Bramson, team Antibody (Nazy, Huynh) & with special thanks to…..12/n
….our participants. People with SSC often have skin changes which makes blood draws especially hard. Thank you for your commitment to our study and huge props to our exceptional phlebotomist/RC Braeden Cowbrough – our unsung hero. 13/n Fin.
Born in September? Then you’re going to want to see Dr. Dawn Bowdish, scientist, and professor of medicine at McMaster University perform “The Perils of Being Born in the Fall” at this year’s Hamilton Fringe Festival (July 17-28th).
Dr. Bowdish is an award-winning scientist and first-time performer in the Hamilton Fringe Festival. Her solo show “The Perils of Being Born in the Fall” tours through the wackiness of early 19th century psychiatry, stealth mid-century reproductive rights activism, how the climate was once thought to affect your sex life, and why cold & flu season has an outsize impact on mental health.
“I’m excited to bring my love for science and science communication to a new audience. In my professional life, I need to provide facts and information in an objective and dispassionate way, but this show provides me an opportunity for me to share my passion, wonder, and amazement at the scientific process while introducing audiences to some quirky and important scientists they almost certainly wouldn’t have heard of before,” Bowdish said.
This show is a fun mix of education and entertainment, and you are guaranteed to leave with fun facts to share with your family and friends.
“The Perils of Being Born in the Fall” will be performed at as part of the Hamilton Fringe Festival at the Hamilton Theatre Inc, 140 M MacNab St N, Hamilton, ON L8R 2M3 at 7 p.m. on July 18,19,20, 25, 26, and 1.pm on July 27,and 28th.
Buy tickets here (or at the venue): https://hftco.ca/events/?mc_cid=eda1dd0bcd&mc_eid=2146b47461
For more information,follow Dr. Bowdish on Bluesky (https://bsky.app/profile/msmacrophage.bsky.social) or Instagram (https://www.instagram.com/msmacrophage/).
Let me tell you about the #BowdishLab & friend’s most recent paper “Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function”, led by Dr. C. Quin (now at @uniofaberdeen.bsky.social) @jclinical-invest.bsky.social https://www.jci.org/articles/view/171002 Tet2 is gene that is involved with methylating genes and therefore changing gene expression. Sometimes spontaneous mutations of Tet2 in hematopoetic stem cells (HSC) occur. These mutants tend to produce more myeloid cells (monocytes/neutrophils). These myeloid producing HSCs tend to be more fit in the aging bone marrow (Darwinian survival of the fittest) and overtime, more and more of your myeloid cells are made from these Tet2 mutant clones. In extreme cases this can lead to myelodysplastic disorders or cancer, but sub-clinical CHIP or clonal hematopoeisis of indeterminant potential occurs in many older adults. People with CHIP (i.e., too many of their myeloid cells are made from Tet2 mutant progenitors) are prone to all sorts of conditions (e.g., heart disease) and pneumonia. We hypothesized that pneumonia risk might be due to changes in innate immune/myeloid cell function. Mice defective in Tet2 did very poorly during Streptococcus pneumoniae infection (the most common cause of community acquired pneumonia in older adults), because their neutrophils were less able to kill bacteria. We are excited about this @jclinical-invest.bsky.social publication because it is the first mechanistic explanation for the increased risk of pneumonia in CHIP. Generally CHIP is thought to affect macrophage function, but it clearly affects neutrophil gene expression & function as well. Many thanks to Dr. Elsa Bou Ghahem for her most excellent Commentary https://www.jci.org/articles/view/181064 and for the great editorial & reviewer experience @jclinical-invest.bsky.social Research Team:Candice Quin, Erica N. DeJong, Elina K. Cook, Yi Zhen Luo, Caitlyn Vlasschaert, Sanathan Sadh, Amy J.M. McNaughton, Marco M. Buttigieg, Jessica A. Breznik, Allison E. Kennedy, Kevin Zhao, Jeffrey Mewburn, Kimberly J. Dunham-Snary, Charles C.T. Hindmarch, Alexander G. Bick, Stephen L. Archer, Michael J. Rauh, Dawn M.E. Bowdish
