Dr. Bowdish speaks about the role of the microbiome in inflammation and healthy/unhealthy aging (starting at 26:02). Other speakers include Dr. Luigi Ferrucci from the NIH Institute of Aging and Dr. James Kirkland who speaks about clinical trials testing senolytics.
Dr Bowdish talks to Scott Thompson on CHML radio about a recent survey suggesting that more Canadians have lost their trust in science. Are scientists elitist? What can scientists do to regain the public’s trust ? Listen to this clip to hear more….
Dr Bowdish is the Canadian Lung Association’s spokesperson for World Pneumonia Day (November 12, 2018). Here she discusses the importance of being vaccinated for pneumonia….
She also speaks to Zoomer Magazine about pneumonia, vaccinations and the aging immune system here…
To get a sense of the other lung research going on in the Bowdish lab, see our Instagram page: house.macrophage
It’s a very serious illness, especially for #Zoomers @libbyznaimer talks with expert @MsMacrophage Dawn Bowdish, Chair of #Aging & Immunity @McMasterU to find out everything we need to know about #Pneumonia at 12 and we take your calls as well at: 416-360-0740 or 1-866-740-4740
— Fight Back w/ Libby (@fightbacklibby) December 27, 2017
Listen to the interview here.
Click here to hear Dawn’s interview with Radio Canada on our recent paper on the role of the microbiome in age-associated inflammtion…
Fiona Whelan and Ryan Buensuceso, sit down with the IIDR’s Dr. Dawn Bowdish to discuss how and why she chose science as a career.
Hear the podcast here.
Novemer 12th is World Pneumonia Day – celebrate by getting vaccinated against influenza and pneumococcal pneumonia!
Hear the interview on Metro Morning with Matt Galloway here:
Read about why older adults should be vaccinated against pneumococcal pneumonia and influenza, as profiled by the CBC here:
To hear Dawn discuss the benefits of vaccination for older adults on London AM 960 The Pulse with Devon Peacock (airdate: Nov 13, 2015) click here:
To read about the link between dementia and pneumonia:
To read about the link between cardiovascular disease and pneumonia
Work in the Bowdish lab is funded by the Canadian taxpayer through the Canadian Institutes of Health Research, the National Science and Engineering Research Council, and through donations administered by the Ontario Lung Association.
As mentioned in an earlier post, Bowdish lab PhD student, Avee Naidoo, won the Fall 2014 CIHR Institute of Aging Anne Martin-Matthews Doctoral Research Prize of Excellence in Research on Aging and is mentioned in the CIHR’s Institute of Aging newsletter!
Research in Lung health is not nearly as well funded as it should be considering the toll it takes on patients and our healthcare system. That’s why the Bowdish lab is involved in the Lung Association’s Breathing as One campaign to raise money for lung research. Click on the picture to read the insert that was delivered in a number of newspapers (including our own Hamilton Spectator) to launch the campaign.
Dawn was thrilled to attend the annual Breathe! gala event hosted as a fundraising event for the Ontario Lung Association to receive an award donated by Pfizer Canada and administered by the Ontario Lung association. Not only did it give her a chance to dress up and go out (a rare event!) for an evening of good food and drink but she was inspired to meet some of the spokespeople of the event, including Helene Campbell, who spent her time waiting for a double lung transplant starting an immensely successful social media campaign to increase organ donation, Ann Marie Cerato, a lung cancer survivor and Kayla Baker, a young sarcoidosis patient on a waiting list for a lung transplant. Not only was it inspiring to meet these brave, bold heroes but it was humbling to be in a room full of people whose lives were all touched by the research funded by the Ontario Lung Association.
So what did Dawn win her award for? You can take a look at the YouTube video here or read on…
Description of research funded by the Ontario Lung Association-Pfizer Ca award
neumonia is the sixth most common cause of death in Canada. The incidence of pneumonia rises steeply in individuals over the age of 65 years and approximately 90% of deaths due to pneumonia occur in the elderly (>65 yrs). Current prevention strategies are inadequate as the vaccination does not prevent pneumonia in most elderly individuals. Recent research from the Bowdish lab demonstrates that one of the reasons the elderly are so susceptible to pneumonia is that their immune systems cannot control the bacteria that normally live in our sinuses. The immune systems of healthy adults can keep the bacteria (Streptococcus pneumoniae) in the sinuses (“pneumococcal carriage”) and eventually clear them, but for reasons we don’t understand, the immune systems of the elderly cannot and as a result the bacteria break through the immune barriers of the sinuses and spread to the lungs, which results in pneumonia.
Although most people think that the elderly get sick because their immune systems “just don’t work”, in fact our data demonstrate that they recruit more white blood cells to the sinuses when they encounter the bacteria that cause pneumonia than healthy adults. Even though they have more white blood cells in the sinuses they don’t seem to be as good at recognizing and killing bacteria. Our goal is to figure out why they have overactive recruitment of white blood cells and why they aren’t as good at killing bacteria as white blood cells from healthy adults.
We have developed what we believe to be the world’s only Aged mouse model of colonization by pneumonia causing bacteria. This allows us to study how the immune system responds to the presence of bacteria in the sinuses in real-time. In addition we have a bank of white blood cells from adults and elderly patients that allow us to confirm the importance of our mouse studies in people.
Hospitalizations and deaths due to pneumonia are unacceptably high in the elderly. This is likely because vaccination of the elderly only does not protect against pneumonia. New methods for preventing infection are urgently required. Our recent data demonstrates that containment and clearance of pneumococcal carriage is impaired in age and results in increased susceptibility to pneumonia; however the mechanisms by which immune control of the sinuses fails remain to be discovered. Prevention of colonization of the sinuses will therefore be essential for control of pneumonia in this population. In order to develop novel therapeutic interventions for the elderly it will be necessary to discover the mechanisms by which bacterial recognition, killing are impaired in the sinuses.