Why humans are uniquely sensitive to wildfire smoke – YouTube Explainer with Dr. Bowdish

Dr. Dawn Bowdish describes how the lab’s NSERC funded research uncovered a link between mutations that protect humans against tuberculosis but leave us susceptible to particulate air pollution.

Read the story here.

Based on the research below:

Bowdish DM, Sakamoto K, Lack NA, Hill PC, Sirugo G, Newport MJ, Gordon S, Hill AV, Vannberg FO. Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population. BMC Med Genet. 2013 Apr 23;14:47. doi: 10.1186/1471-2350-14-47. PMID: 23617307; PMCID: PMC3652798.

Novakowski KE, Huynh A, Han S, Dorrington MG, Yin C, Tu Z, Pelka P, Whyte P, Guarné A, Sakamoto K, Bowdish DM. A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function. Immunol Cell Biol. 2016 Aug;94(7):646-55. doi: 10.1038/icb.2016.20. Epub 2016 Feb 18. PMID: 26888252; PMCID: PMC4980223.

Novakowski KE, Yap NVL, Yin C, Sakamoto K, Heit B, Golding GB, Bowdish DME. Human-Specific Mutations and Positively Selected Sites in MARCO Confer Functional Changes. Mol Biol Evol. 2018 Feb 1;35(2):440-450. doi: 10.1093/molbev/msx298. PMID: 29165618; PMCID: PMC5850514.

Also featured in the New York Times “Air Pollution, Evolution and The Fate of Billions of Humans” by Carl Zimmer

https://www.nytimes.com/2020/01/13/science/air-pollution-fires-genes.html

Dr Bowdish speaks on Defy Dementia™ Episode 35: A Shot at Prevention? The Shingles Vaccine & Dementia Risk

Listen to the epidsode here.

Could a routine vaccine help protect your brain? In this episode, we explore emerging research on the association between shingles vaccination and reduced dementia risk. Ron Swan shares his perspective as a community advocate focused on aging and accessibility, while Dr. Dawn Bowdish (Professor, McMaster University) breaks down what the science says, and what it doesn’t, about how vaccines may influence brain health. Together, they unpack what shingles is and what “promising but early” research about shingles vaccination could mean for reducing dementia risk.

Tune in at defydementia.org, or wherever you get your podcasts.

Web resources

Link between shingles vaccine and slowed dementia is ‘promising’ says expert – from Harvard School of Public Health




For those living with dementia, new study suggests shingles vaccine could slow the disease – from Standford Medicine




‘Strong evidence’ of lowered dementia risk: the benefits of shingles vaccination – from The Guardian





Can a routine vaccine prevent dementia? – from Harvard Health Publishing, Harvard Medical School





Is dementia a vaccine preventable condition? – from Bowdish Lab, Macrophage Biology at McMaster University





Guests:

Ron Swan
Ron Swan is a retired business development professional and entrepreneur with a strong focus on accessibility and aging-in-place. He founded Home Safe Living, a company that provided independent living and accessibility solutions across the Maritime region before selling the business to Lawton’s Drugs, a Sobeys company.





A passionate advocate for older adults, Ron continues to contribute through leadership roles, including Chair of the Board of CARP Nova Scotia and past Chair of the Seniors’ Advisory Council of Nova Scotia. He is frequently called upon to speak on aging, accessibility and community well-being.





Dr. Dawn Bowdish
Dr. Bowdish is a Professor at McMaster University and Executive Director of the Firestone Institute of Respiratory Health. Her research focuses on how aging affects the immune system, particularly how inflammation alters immune cell function and increases susceptibility to infections.Her work also examines how the aging immune system interacts with the microbiome and how these processes influence healthy and unhealthy aging. Dr. Bowdish leads the Preclinical Studies in Aging Laboratory and serves on the Board of Directors of the Lung Health Foundation, where she advocates for improved lung health and research funding for older adults.


Dr. Dawn Bowdish takes on a new leadership role with the Lung Health Foundation.

This week Dr Bowdish had the honour and privilege of becoming the next Vice-Chair of the Lung Health Foundation‘s Board of Directors. The Lung Health Foundation is Canada’s largest non-profit working to improve the lives of people living with lung conditions. Dr. Bowdish has been a Board member since 2015 where she has helped support the Lung Health Foundation’s advocacy, research, and education. She is looking forward to continuing this work and getting even more involved with this excellent organization. Lung Health starts now!

https://www.linkedin.com/feed/update/urn:li:activity:7476027081840017408/

Dr. Bowdish discusses measles elimination on TVO’s ‘The Rundown’

In 1998, Canada celebrated a huge milestone. We became one of the first countries in the world to eliminate measles. Twenty-seven years later, things are dramatically different. That’s because one year ago in New Brunswick, measles made a reappearance. What started as one case quickly spread across the country. And has continued to spread for a full year. Pay attention to that one-year mark, because it’s important. According to public health, if the chain of transmission can’t be broken in a year, it means a country can no longer call itself measles-free. Canada’s status will officially be determined at a meeting next month. We have had outbreaks since 1998, but we’ve always been able to break the chain of transmission. But not this time. Spread has been slowing. But it’s still making headlines. Like possible exposures this month in Ottawa. And Alberta recently reported its first measles death since the outbreak began. So—how did we get here? And what would it take to make measles a disease of the past. Again?

Dr. Bowdish is a panelist at the National Vaccine Summit on Adult Vaccination.

Over the past 50 years, immunizations have saved more lives in Canada than any other health intervention. With the help of a doctor, an immunologist, a pharmacist and a patient advocate, Zoomer Radio’s Liz West leads this discussion about vaccines – what’s available, where and why we need them.
National Vaccine Summit
‣ Recommended Vaccines & How To Get Them
‣ Navigating Provincial Health Systems
‣ The Role Your Pharmacist Can Play
‣ Emerging Science
‣ Fighting Disinformation & Vaccine Fatigue