Class A Scavenger Receptor Blocking Protocol

• This protocol uses the scavenger receptor inhibitors dextran sulphate and polyI (and control ligands) to block scavenger receptor binding and is used whether ligand binding occurs by the class A scavenger receptors.
• Citation: Bowdish DM, et al. MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis.PLoS Pathog. 2009 Jun;5(6):e1000474. doi: 10.1371/journal.ppat.1000474.

Genotyping Scavenger Receptor A and MARCO (Msr1 & Marco) knockout mice