{"id":2596,"date":"2018-10-06T15:14:32","date_gmt":"2018-10-06T19:14:32","guid":{"rendered":"https:\/\/www.bowdish.ca\/lab\/?p=2596"},"modified":"2018-10-06T15:36:44","modified_gmt":"2018-10-06T19:36:44","slug":"publication-myeloid-derived-suppressor-cells-in-aged-humans","status":"publish","type":"post","link":"https:\/\/www.bowdish.ca\/lab\/2018\/10\/06\/publication-myeloid-derived-suppressor-cells-in-aged-humans\/","title":{"rendered":"Publication: Myeloid-Derived Suppressor Cells in Aged Humans"},"content":{"rendered":"<p><a href=\"https:\/\/link.springer.com\/referenceworkentry\/10.1007\/978-3-319-64597-1_96-1\">Myeloid-Derived Suppressor Cells in Aged Humans<\/a><\/p>\n<p>Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells whose<br \/>\nimmunosuppressive activities contribute to cancer and other diseases. MDSCs<br \/>\nappear to increase with age, and this presumably contributes to immunosuppression<br \/>\nand the increased incidence of certain diseases. Why MDSCs increase with<br \/>\nage is not entirely clear. Herein we present evidence that MDSC expansion is due<br \/>\nin part to age-related changes in hematopoiesis, including the acquisition of<br \/>\nmutations that favor myelopoiesis, which are compounded by changes in the<br \/>\naging microenvironment that favor the production of MDSCs.<\/p>\n<p><iframe loading=\"lazy\" src=\"https:\/\/www.bowdish.ca\/lab\/wp-content\/uploads\/2018\/10\/Rauh2018_ReferenceWorkEntry_Myeloid-DerivedSuppressorCells.pdf\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Myeloid-Derived Suppressor Cells in Aged Humans Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells whose immunosuppressive activities contribute to cancer and other diseases. MDSCs appear to increase with age, and this presumably contributes to immunosuppression and the increased incidence of &hellip; <a href=\"https:\/\/www.bowdish.ca\/lab\/2018\/10\/06\/publication-myeloid-derived-suppressor-cells-in-aged-humans\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,85],"tags":[59,52,87,39],"class_list":["post-2596","post","type-post","status-publish","format-standard","hentry","category-news","category-publications","tag-aging","tag-immunosenescence","tag-inflammation","tag-publication"],"_links":{"self":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/posts\/2596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/comments?post=2596"}],"version-history":[{"count":3,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/posts\/2596\/revisions"}],"predecessor-version":[{"id":2600,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/posts\/2596\/revisions\/2600"}],"wp:attachment":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/media?parent=2596"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/categories?post=2596"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/tags?post=2596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}