{"id":1979,"date":"2016-06-18T09:09:58","date_gmt":"2016-06-18T13:09:58","guid":{"rendered":"https:\/\/www.bowdish.ca\/lab\/?p=1979"},"modified":"2023-12-30T22:58:24","modified_gmt":"2023-12-31T03:58:24","slug":"publication-streptococcus-pneumoniae-colonization-disrupts-the-microbial-community-within-the-upper-respiratory-tract-of-aging-mice","status":"publish","type":"post","link":"https:\/\/www.bowdish.ca\/lab\/2016\/06\/18\/publication-streptococcus-pneumoniae-colonization-disrupts-the-microbial-community-within-the-upper-respiratory-tract-of-aging-mice\/","title":{"rendered":"Publication: Streptococcus pneumoniae Colonization Disrupts the Microbial Community within the Upper Respiratory Tract of Aging Mice"},"content":{"rendered":"<p>Colonization of <i>Streptococcus pneumoniae<\/i> within the upper respiratory tract (URT) of elderly individuals is a major concern, as it often results in the development of pneumonia, which can be deadly in this population. A study published by MIRC Masters\u2019 student <strong>Netusha Thevaranjan<\/strong>, under the supervision of <strong>Dr. Dawn Bowdish<\/strong>, examined how<a href=\"https:\/\/www.bowdish.ca\/lab\/wp-content\/uploads\/2013\/06\/Netusha-sm.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-1004\" src=\"https:\/\/www.bowdish.ca\/lab\/wp-content\/uploads\/2013\/06\/Netusha-sm.jpg\" alt=\"Netusha-sm\" width=\"181\" height=\"208\" \/><\/a> aging can change the composition of the respiratory microbial community and consequently, impact bacterial colonization. Using a mouse model of pneumococcal colonization, the study characterized the composition of the URT microbiota in young, middle-aged, and old mice in both the na\u00efve state, and throughout the course of nasopharyngeal colonization with <i>S. pneumoniae<\/i>. It was shown that the composition of the URT microbiota differs with age, and that colonization with <i>S. pneumoniae <\/i>in older mice disrupted pre-existing microbial communities.<\/p>\n<p>Furthermore, the study demonstrated that there were several interspecies interactions between <i>S. pneumoniae <\/i>and resident microbes. In particular,<i>Streptococcus<\/i> interacted competitively with <i>Staphylococcus<\/i> and synergistically with <i>Haemophilus<\/i>. This work provides insight into how aging influences bacterial colonization, and understanding the relationship between these two factors can help create strategies to protect the elderly from age-associated infections and disease. <a href=\"http:\/\/iai.asm.org\/content\/84\/4\/906.short\">Read More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Colonization of Streptococcus pneumoniae within the upper respiratory tract (URT) of elderly individuals is a major concern, as it often results in the development of pneumonia, which can be deadly in this population. A study published by MIRC Masters\u2019 student &hellip; <a href=\"https:\/\/www.bowdish.ca\/lab\/2016\/06\/18\/publication-streptococcus-pneumoniae-colonization-disrupts-the-microbial-community-within-the-upper-respiratory-tract-of-aging-mice\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,85],"tags":[59,73,11,52,57,39,21],"class_list":["post-1979","post","type-post","status-publish","format-standard","hentry","category-news","category-publications","tag-aging","tag-bioinformatics","tag-graduate-students","tag-immunosenescence","tag-microbiome","tag-publication","tag-streptococcus-pneumoniae"],"_links":{"self":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/posts\/1979","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/comments?post=1979"}],"version-history":[{"count":1,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/posts\/1979\/revisions"}],"predecessor-version":[{"id":1980,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/posts\/1979\/revisions\/1980"}],"wp:attachment":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/media?parent=1979"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/categories?post=1979"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/tags?post=1979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}