{"id":107,"date":"2009-03-31T19:30:13","date_gmt":"2009-04-01T00:30:13","guid":{"rendered":"https:\/\/www.bowdish.ca\/lab\/?p=107"},"modified":"2009-05-12T20:38:07","modified_gmt":"2009-05-13T01:38:07","slug":"dawn-receives-funding-from-the-iidr-to-study-the-role-of-macrophages-in-pneumococcal-disease","status":"publish","type":"post","link":"https:\/\/www.bowdish.ca\/lab\/2009\/03\/31\/dawn-receives-funding-from-the-iidr-to-study-the-role-of-macrophages-in-pneumococcal-disease\/","title":{"rendered":"Dawn receives funding from the IIDR to study the role of macrophages in pneumococcal disease"},"content":{"rendered":"<p>The <a href=\"http:\/\/iidr.mcmaster.ca\/about-the-institute\/index.html\">IIDR<\/a> has awarded the Bowdish lab seed money to study the role of macrophages in host response to colonization by <em>Streptococcus pneumoniae<\/em>. <em>S. pneumoniae <\/em>infections can range from treatable (respiratory tract infections, otitis) to life-threatening (meningitis, sepsis). The introduction of the pneumococcal conjugate vaccine (PCV) has shifted the epidemiology of <em>S. pneumoniae<\/em> infections but not eliminated them.\u00a0 In humans, colonization of the upper respiratory tract is the initial step in pathogenesis. This is accompanied by a robust antibody response, which is generally believed to be required for clearance (and thus prevention of infection); however, data for this is not supported by clinical observations in which high levels of antibodies are not associated with clearance or in which immunodeficient patients susceptible to pneumococcal infections can produce robust anti-pneumococcal antibody responses while still being prone to recurrent systemic infections.\u00a0 The aim of this project is to assess the importance of macrophages in the recognition and clearance of <em>S. pneumoniae<\/em> in the upper respiratory tract.\u00a0\u00a0 This work will be done in collaboration with Prof. Jeffrey Weiser at the University of Pennsylvania who is a world leader in the field of <em>S. pneumoniae<\/em> pathogenesis. Dawn will be travelling to his lab in July to learn from his lab members.\u00a0 The Bowdish lab is currently recruiting graduate students and post-docs who are interested in the host response to <em>S. pneumoniae <\/em>infection and colonization.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The IIDR has awarded the Bowdish lab seed money to study the role of macrophages in host response to colonization by Streptococcus pneumoniae. S. pneumoniae infections can range from treatable (respiratory tract infections, otitis) to life-threatening (meningitis, sepsis). The introduction &hellip; <a href=\"https:\/\/www.bowdish.ca\/lab\/2009\/03\/31\/dawn-receives-funding-from-the-iidr-to-study-the-role-of-macrophages-in-pneumococcal-disease\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[22,11,3,25,23,12,21],"class_list":["post-107","post","type-post","status-publish","format-standard","hentry","category-news","tag-collaborator","tag-graduate-students","tag-grant","tag-host-defence","tag-iidr","tag-macrophage","tag-streptococcus-pneumoniae"],"_links":{"self":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/posts\/107","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/comments?post=107"}],"version-history":[{"count":5,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/posts\/107\/revisions"}],"predecessor-version":[{"id":139,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/posts\/107\/revisions\/139"}],"wp:attachment":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/media?parent=107"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/categories?post=107"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/tags?post=107"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}