{"id":3422,"date":"2024-01-01T22:28:01","date_gmt":"2024-01-02T03:28:01","guid":{"rendered":"https:\/\/www.bowdish.ca\/lab\/?page_id=3422"},"modified":"2026-01-03T07:43:40","modified_gmt":"2026-01-03T12:43:40","slug":"vaccination-and-infection-in-older-adults","status":"publish","type":"page","link":"https:\/\/www.bowdish.ca\/lab\/vaccination-and-infection-in-older-adults\/","title":{"rendered":"Vaccination and infection in older adults"},"content":{"rendered":"\n

Project Description:<\/h2>\n\n\n\n

As we get older our risk of developing serious respiratory infections increases. Concurrently, the aging immune system is continually remodelled by environmental exposures, infections, medications, and chronic conditions such as frailty. We aim to understand how the aging immune system impacts responses to vaccination and infection. <\/p>\n\n\n\n

Our ongoing investigations include;<\/p>\n\n\n\n

  1. Quantitating immune responses to vaccination (i.e., COVID-19, and others) in older adults including older adults living in long-term care<\/li>
  2. Discovering how immunomodulatory drugs impact vaccination responses.<\/li>
  3. Using pre-clinical models to understand how immune responses to bacterial pneumonia change with age. <\/li><\/ol>\n\n\n\n

    Team Members:<\/strong>
    Technical lead<\/em>: Braeden Cowborough
    Post-doctoral fellow: Dr Jessica Breznik
    Graduate students:<\/em> Jenna Benoit (PhD candidate)
    <\/p>\n\n\n\n

    Publications:<\/h2>\n\n\n\n
    \n1. \n<\/td>\n\nImmunomodulatory drugs have divergent effects\n on humoral and cellular immune responses to SARS-CoV-2 vaccination in people living with rheumatoid arthritis.\n<\/a>\n\nBenoit JM, Breznik JA, Ang JC, \nBhakta H, Huynh A, Cowbrough B, Baker B, Heessels L, Lodhi S, Yan E, \nEwusie J, Nazy I, Bramson J, Miller MS, Bernatsky S, Larch\u00e9 MJ, Bowdish \nDME; SUCCEED Investigator Group.\nSci Rep. 2023 Dec 21;13(1):22846. doi: 10.1038\/s41598-023-50263-5.\nPMID: 38129594\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n2. \n<\/td>\n\nEarly\n humoral and cellular responses after\n bivalent SARS-CoV-2 mRNA-1273.214 vaccination in long-term care and \nretirement home residents in Ontario, Canada: An observational cohort \nstudy.\n<\/a>\n\nBreznik JA, Rahim A, Bhakta H, \nClare R, Zhang A, Ang J, Stacey HD, Liu LM, Kennedy A, Bilaver L, \nHagerman M, Kajaks T, Bramson JL, Nazy I, Miller MS, Costa AP, Bowdish \nDME; COVID in LTC Investigator Group.\nJ Med Virol. 2023 Oct;95(10):e29170. doi: 10.1002\/jmv.29170.\nPMID: 37822054\n\n\n\n<\/td><\/tr>
    \n3. \n<\/td>\n\nEarly Omicron infection is associated with\n increased reinfection risk in older adults in long-term care and retirement facilities.\n<\/a>\n\nBreznik JA, Rahim A, Zhang A, \nAng J, Stacey HD, Bhakta H, Clare R, Liu LM, Kennedy A, Hagerman M, \nKajaks T, Miller MS, Nazy I, Bramson JL, Costa AP, Bowdish DME.\nEClinicalMedicine. 2023 Aug 21;63:102148. doi: 10.1016\/j.eclinm.2023.102148. eCollection 2023 Sep.\nPMID: 37753447\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n4. \n<\/td>\n\nProtocol for a living evidence synthesis on\n variants of concern and COVID-19 vaccine effectiveness. <\/a>\n\nShaver N, Katz M, Darko Asamoah\n G, Linkins LA, Abdelkader W, Beck A, Bennett A, Hughes SE, Smith M, \nBegin M, Coyle D, Piggott T, Kagina BM, Welch V, Colijn C, Earn DJD, El \nEmam K, Heffernan J, O’Brien SF, Wilson K, Collins\n E, Navarro T, Beyene J, Boutron I, Bowdish D, Cooper C, Costa A, Curran\n J, Griffith L, Hsu A, Grimshaw J, Langlois MA, Li X, Pham-Huy A, Raina \nP, Rubini M, Thabane L, Wang H, Xu L, Brouwers M, Horsley T, Lavis J, \nIorio A, Little J.\nVaccine. 2023 Oct 13;41(43):6411-6418. doi: 10.1016\/j.vaccine.2023.09.012. Epub 2023 Sep 16.\nPMID: 37718186\nReview. \n\n\n<\/td><\/tr>
    \n5. \n<\/td>\n\nProtection from Omicron Infection in Residents\n of Nursing and Retirement Homes in Ontario, Canada. <\/a>\n\nBreznik JA, Rahim A, Kajaks T, \nHagerman M, Bilaver L, Colwill K, Dayam RM, Gingras AC, Verschoor CP, \nMcElhaney JE, Bramson JL, Bowdish DME, Costa AP.\nJ Am Med Dir Assoc. 2023 May;24(5):753-758. doi: 10.1016\/j.jamda.2023.02.105. Epub 2023 Mar 28.\nPMID: 37001559\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n6. \n<\/td>\n\nCoronavirus\n Disease 2019 Vaccination Is Associated\n With Reduced Outpatient Antibiotic Prescribing in Older Adults With \nConfirmed Severe Acute Respiratory Syndrome Coronavirus 2: A \nPopulation-Wide Cohort Study.\n<\/a>\n\nMacFadden DR, Maxwell C, \nBowdish D, Bronskill S, Brooks J, Brown K, Burrows LL, Clarke A, \nLangford B, Leung E, Leung V, Manuel D, McGeer A, Mishra S, Morris AM, \nNott C, Raybardhan S, Sapin M, Schwartz KL, So M, Soucy\n JR, Daneman N.\nClin Infect Dis. 2023 Aug 14;77(3):362-370. doi: 10.1093\/cid\/ciad190.\nPMID: 36999314\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n7. \n<\/td>\n\nComparison\n of three dosing intervals for the\n primary vaccination of the SARS-CoV-2 mRNA Vaccine (BNT162b2) on \nmagnitude, neutralization capacity and durability of the humoral immune \nresponse in health care workers: A prospective cohort study.\n<\/a>\n\nLeong DP, Zhang A, Breznik JA, \nClare R, Huynh A, Mushtaha M, Rangarajan S, Stacey H, Kim PY, Loeb M, \nDenburg JA, Mertz D, Chagla Z, Nazy I, Miller MS, Bowdish DME, Duong M.\nPLoS One. 2023 Feb 15;18(2):e0281673. doi: 10.1371\/journal.pone.0281673. eCollection 2023.\nPMID: 36791069\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n8. \n<\/td>\n\nCytomegalovirus Seropositivity in Older Adults\n Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination.\n<\/a>\n\nBreznik JA, Huynh A, Zhang A, \nBilaver L, Bhakta H, Stacey HD, Ang JC, Bramson JL, Nazy I, Miller MS, \nDenburg J, Costa AP, Bowdish DME; other members of the COVID-in-LTC \nInvestigator Group.\nJ Immunol. 2022 Nov 15;209(10):1892-1905. doi: 10.4049\/jimmunol.2200369.\nPMID: 36426948\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n9. \n<\/td>\n\nSeropositivity and risk factors for SARS-CoV-2\n infection in a South Asian community in Ontario: a cross-sectional analysis of a prospective cohort study.\n<\/a>\n\nAnand SS, Arnold C, Bangdiwala \nSI, Bolotin S, Bowdish D, Chanchlani R, de Souza RJ, Desai D, Kandasamy \nS, Khan F, Khan Z, Langlois MA, Limbachia J, Lear SA, Loeb M, Loh L, \nManoharan B, Nakka K, Pelchat M, Punthakee Z,\n Schulze KM, Williams N, Wahi G.\nCMAJ Open. 2022 Jul 5;10(3):E599-E609. doi: 10.9778\/cmajo.20220031. Print 2022 Jul-Sep.\nPMID: 35790229\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n10. \n<\/td>\n\nErythro-VLPs: Anchoring SARS-CoV-2 spike proteins\n in erythrocyte liposomes. <\/a>\n\nHimbert S, Gastaldo IP, Ahmed \nR, Pomier KM, Cowbrough B, Jahagirdar D, Ros S, Juhasz J, St\u00f6ver HDH, \nOrtega J, Melacini G, Bowdish DME, Rheinst\u00e4dter MC.\nPLoS One. 2022 Mar 11;17(3):e0263671. doi: 10.1371\/journal.pone.0263671. eCollection 2022.\nPMID: 35275926\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n11. \n<\/td>\n\nAntibody Responses to Third-Dose mRNA Vaccines\n in Nursing Home and Assisted Living Residents. <\/a>\n\nZhang A, Breznik JA, Clare R, Nazy I, Miller MS, Bowdish DME, Costa AP.\nJ Am Med Dir Assoc. 2022 Mar;23(3):444-446. doi: 10.1016\/j.jamda.2021.12.035. Epub 2022 Jan 15.\nPMID: 35041829\nFree PMC article.\nNo abstract available.\n\n\n\n<\/td><\/tr>
    \n12. \n<\/td>\n\nAntibody Responses 3-5 Months Post-Vaccination\n with mRNA-1273 or BNT163b2 in Nursing Home Residents. <\/a>\n\nBreznik JA, Zhang A, Huynh A, Miller MS, Nazy I, Bowdish DME, Costa AP.\nJ Am Med Dir Assoc. 2021 Dec;22(12):2512-2514. doi: 10.1016\/j.jamda.2021.10.001. Epub 2021 Nov 1.\nPMID: 34736891\nFree PMC article.\nNo abstract available.\n\n\n\n<\/td><\/tr>
    \n13. \n<\/td>\n\nDNA methylation patterns are related to co-morbidity\n status and circulating C-reactive protein levels in the nursing home elderly. <\/a>\n\nVerschoor CP, McEwen LM, Kobor MS, Loeb MB, Bowdish DME.\nExp Gerontol. 2018 May;105:47-52. doi: 10.1016\/j.exger.2017.10.010. Epub 2017 Oct 12.\nPMID: 29032243\n\n\n\n<\/td><\/tr>
    \n14. \n<\/td>\n\nSerum C-Reactive Protein and Congestive Heart\n Failure as Significant Predictors of Herpes Zoster Vaccine Response in Elderly Nursing Home Residents.\n<\/a>\n\nVerschoor CP, Lelic A, Parsons R, Evelegh C, Bramson JL, Johnstone J, Loeb MB, Bowdish DME.\nJ Infect Dis. 2017 Jul 15;216(2):191-197. doi: 10.1093\/infdis\/jix257.\nPMID: 28838148\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n15. \n<\/td>\n\nImmunogenicity of Varicella Vaccine and Immunologic\n Predictors of Response in a Cohort of Elderly Nursing Home Residents. <\/a>\n\nLelic A, Verschoor CP, Lau VW, Parsons R, Evelegh C, Bowdish DM, Bramson JL, Loeb MB.\nJ Infect Dis. 2016 Dec 15;214(12):1905-1910. doi: 10.1093\/infdis\/jiw462. Epub 2016 Oct 5.\nPMID: 27707807\n\n\n\n<\/td><\/tr>
    \n16. \n<\/td>\n\nBroadly Neutralizing Hemagglutinin Stalk-Specific\n Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner.\n<\/a>\n\nMullarkey CE, Bailey MJ, Golubeva DA, Tan GS, Nachbagauer R, He W, Novakowski KE, Bowdish DM, Miller MS, Palese P.\nmBio. 2016 Oct 4;7(5):e01624-16. doi: 10.1128\/mBio.01624-16.\nPMID: 27703076\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n17. \n<\/td>\n\nPrivileged Antigen Presentation in Splenic\n B Cell Follicles Maximizes T Cell Responses in Prime-Boost Vaccination. <\/a>\n\nBridle BW, Nguyen A, Salem O, Zhang L, Koshy S, Clouthier D, Chen L, Pol J, Swift SL, Bowdish DM, Lichty BD, Bramson JL, Wan Y.\nJ Immunol. 2016 Jun 1;196(11):4587-95. doi: 10.4049\/jimmunol.1600106. Epub 2016 Apr 27.\nPMID: 27183620\n\n\n\n<\/td><\/tr>
    \n18. \n<\/td>\n\nMicroneutralization assay titres correlate\n with protection against seasonal influenza H1N1 and H3N2 in children. <\/a>\n\nVerschoor CP, Singh P, Russell ML, Bowdish DM, Brewer A, Cyr L, Ward BJ, Loeb M.\nPLoS One. 2015 Jun 24;10(6):e0131531. doi: 10.1371\/journal.pone.0131531. eCollection 2015.\nPMID: 26107625\nFree PMC article.\nClinical Trial.\n\n\n\n<\/td><\/tr>
    \n19. \n<\/td>\n\nImmunosenescence and novel vaccination strategies\n for the elderly. <\/a>\n\nDorrington MG, Bowdish DM.\nFront Immunol. 2013 Jun 28;4:171. doi: 10.3389\/fimmu.2013.00171. Print 2013.\nPMID: 23825474\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n20. \n<\/td>\n\nThe polyfunctionality of human memory CD8+\n T cells elicited by acute and chronic virus infections is not influenced by age.\n<\/a>\n\nLelic A, Verschoor CP, Ventresca M, Parsons R, Evelegh C, Bowdish D, Betts MR, Loeb MB, Bramson JL.\nPLoS Pathog. 2012;8(12):e1003076. doi: 10.1371\/journal.ppat.1003076. Epub 2012 Dec 13.\nPMID: 23271970\nFree PMC article.\nClinical Trial.\n\n\n<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"

    Project Description: As we get older our risk of developing serious respiratory infections increases. Concurrently, the aging immune system is continually remodelled by environmental exposures, infections, medications, and chronic conditions such as frailty. We aim to understand how the aging … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":3736,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3422","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/pages\/3422","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/comments?post=3422"}],"version-history":[{"count":2,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/pages\/3422\/revisions"}],"predecessor-version":[{"id":3747,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/pages\/3422\/revisions\/3747"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/media\/3736"}],"wp:attachment":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/media?parent=3422"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}