{"id":3408,"date":"2023-12-30T22:50:32","date_gmt":"2023-12-31T03:50:32","guid":{"rendered":"https:\/\/www.bowdish.ca\/lab\/?page_id=3408"},"modified":"2026-01-03T07:44:02","modified_gmt":"2026-01-03T12:44:02","slug":"age-pneumonia-and-post-pneumonia-health-issues","status":"publish","type":"page","link":"https:\/\/www.bowdish.ca\/lab\/current-projects\/age-pneumonia-and-post-pneumonia-health-issues\/","title":{"rendered":"Age, pneumonia, and post-pneumonia health issues"},"content":{"rendered":"\n

Project Description:<\/h2>\n\n\n\n

Having pneumonia in mid- to late-life accelerates or exacerbates other health conditions such as cognitive decline, cardiovascular issues, and frailty. Because we don’t know why this occurs, the only way to prevent it is to reduce the risk of infection by vaccination. We don’t have vaccines against all the pathogens that cause pneumonia and even if we did, not all older adults respond perfectly to vaccines. Our vision is to understand how pneumonia causes long-term health issues and test interventions in our pre-clinical models to develop new treatments. <\/p>\n\n\n\n

Our ongoing investigations include;<\/p>\n\n\n\n

  1. Understanding how age-related changes in the immune response increase the risk of pneumonia. <\/li>
  2. Using large population-based studies to understand how pneumonia and chronic inflammation impact cognition (led by collaborator Dr. Chris Verschoor<\/a>) <\/li>
  3. Understanding how chronic age-associated inflammation impact microglia (brain macrophage) function<\/li>
  4. Uncovering mechanisms by which pneumonia impacts cognition and accelerates frailty.<\/li>
  5. Testing new drugs to prevent post-pneumonia cognitive decline. <\/li><\/ol>\n\n\n\n

    Team Members:<\/strong>
    Technical lead<\/em>: Braeden Cowborough
    Graduate students:<\/em> Sofya Ermolina (PhD)
    Undergraduate students:<\/em>  Molly Health, Amanda Densil<\/p>\n\n\n\n

    Current Funding:<\/strong> CIHR Brain Aging Team Grant (co-PI, Dr Chris Verschoor, co-investigators Drs A. Costa, A. Jones, M. Chong, K. Choe, C. Quin, J. Kwong, M. Tremblay)<\/p>\n\n\n\n

    Publications:<\/h2>\n\n\n\n
    \n1. \n<\/td>\n\nAcute organ injury and long-term sequelae of\n severe pneumococcal infections. <\/a>\n\nKruckow KL, Zhao K, Bowdish DME, Orihuela CJ.\nPneumonia (Nathan). 2023 Mar 5;15(1):5. doi: 10.1186\/s41479-023-00110-y.\nPMID: 36870980\nFree PMC article.\nReview. \n\n\n<\/td><\/tr>
    \n2. \n<\/td>\n\nAutoantibody-mediated Macrophage Dysfunction\n in Patients with Severe Asthma with Airway Infections. <\/a>\n\nSon K, Miyasaki K, Salter B, \nLoukov D, Chon J, Zhao N, Radford K, Huang C, LaVigne N, Dvorkin-Gheva \nA, Lacy P, Ho T, Bowdish DME, Nair P, Mukherjee M.\nAm J Respir Crit Care Med. 2023 Feb 15;207(4):427-437. doi: 10.1164\/rccm.202206-1183OC.\nPMID: 36287613\n\n\n\n<\/td><\/tr>
    \n3. \n<\/td>\n\nAge-Associated Microbial Dysbiosis Promotes\n Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. <\/a>\n\nThevaranjan N, Puchta A, Schulz\n C, Naidoo A, Szamosi JC, Verschoor CP, Loukov D, Schenck LP, Jury J, \nFoley KP, Schertzer JD, Larch\u00e9 MJ, Davidson DJ, Verd\u00fa EF, Surette MG, \nBowdish DME.\nCell Host Microbe. 2017 Apr 12;21(4):455-466.e4. doi: 10.1016\/j.chom.2017.03.002.\nPMID: 28407483\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n4. \n<\/td>\n\nTNF Drives Monocyte Dysfunction with Age and\n Results in Impaired Anti-pneumococcal Immunity. <\/a>\n\nPuchta A, Naidoo A, Verschoor \nCP, Loukov D, Thevaranjan N, Mandur TS, Nguyen PS, Jordana M, Loeb M, \nXing Z, Kobzik L, Larch\u00e9 MJ, Bowdish DM.\nPLoS Pathog. 2016 Jan 14;12(1):e1005368. doi: 10.1371\/journal.ppat.1005368. eCollection 2016 Jan.\nPMID: 26766566\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n5. \n<\/td>\n\nAnti-pneumococcal deficits of monocyte-derived\n macrophages from the advanced-age, frail elderly and related impairments in PI3K-AKT signaling.\n<\/a>\n\nVerschoor CP, Johnstone J, Loeb M, Bramson JL, Bowdish DM.\nHum Immunol. 2014 Dec;75(12):1192-6. doi: 10.1016\/j.humimm.2014.10.004. Epub 2014 Oct 13.\nPMID: 25446401\n\n\n\n<\/td><\/tr>
    \n6. \n<\/td>\n\nCharacterization of inflammatory responses\n during intranasal colonization with Streptococcus pneumoniae. <\/a>\n\nPuchta A, Verschoor CP, Thurn T, Bowdish DM.\nJ Vis Exp. 2014 Jan 17;(83):e50490. doi: 10.3791\/50490.\nPMID: 24472828\nFree PMC article.\n\n\n<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

    Project Description: Having pneumonia in mid- to late-life accelerates or exacerbates other health conditions such as cognitive decline, cardiovascular issues, and frailty. Because we don’t know why this occurs, the only way to prevent it is to reduce the risk … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":3733,"parent":48,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3408","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/pages\/3408","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/comments?post=3408"}],"version-history":[{"count":2,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/pages\/3408\/revisions"}],"predecessor-version":[{"id":3748,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/pages\/3408\/revisions\/3748"}],"up":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/pages\/48"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/media\/3733"}],"wp:attachment":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/media?parent=3408"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}