{"id":3378,"date":"2023-12-28T22:47:36","date_gmt":"2023-12-29T03:47:36","guid":{"rendered":"https:\/\/www.bowdish.ca\/lab\/?page_id=3378"},"modified":"2026-01-03T07:44:36","modified_gmt":"2026-01-03T12:44:36","slug":"the-role-of-the-microbiota-in-healthy-unhealthy-aging","status":"publish","type":"page","link":"https:\/\/www.bowdish.ca\/lab\/current-projects\/the-role-of-the-microbiota-in-healthy-unhealthy-aging\/","title":{"rendered":"The role of the microbiota in healthy\/unhealthy aging"},"content":{"rendered":"\n

Project Description<\/strong>:<\/h1>\n\n\n\n

Our immune system and the microbes that live on and in us change as we age, but whether these changes contribute to healthy\/unhealthy aging is not clear. We perform mechanistic experiments to understand whether age-related changes in the microbiota or immunes system have a causal relationship with healthy\/unhealthy aging.<\/p>\n\n\n\n

We have a number of ongoing projects;<\/p>\n\n\n\n

  1. Understanding how the gut microbiota changes with age and contributes to a ‘leaky gut’, that triggers inflammation. <\/li>
  2. Determine if the gut microbiome causes or accelerates frailty<\/li>
  3. Determine whether the upper respiratory tract microbiota changes with age and whether this contributes to susceptibility to infection. <\/li><\/ol>\n\n\n\n

    Team Members:<\/strong>
    Technical lead<\/em>: Erica DeJong (lab manager)
    Graduate students:<\/em> Alice Caldwell (MSc)
    Undergraduate students:<\/em>  Catherine Andary (Medical student)<\/p>\n\n\n\n

    Current Funding:<\/strong> CIHR Project Grant, Weston Family Foundation Grant<\/p>\n\n\n\n

    Collaborators:<\/strong>
    Dr. Michael Surette
    Dr. Elena Verd\u00fa
    Dr. Pratheepa Jeganathan<\/p>\n\n\n\n

    Publications:<\/h2>\n\n\n\n
    \n1. \n<\/td>\n\nNasal Tissue Extraction Is Essential for Characterization\n of the Murine Upper Respiratory Tract Microbiota. <\/a>\n\nSchenck LP, McGrath JJC, Lamarche D, St\u00e4mpfli MR, Bowdish DME, Surette MG.\nmSphere. 2020 Dec 16;5(6):e00562-20. doi: 10.1128\/mSphere.00562-20.\nPMID: 33328347\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n2. \n<\/td>\n\nThe Gut Microbiota and Unhealthy Aging: Disentangling\n Cause from Consequence. <\/a>\n\nDeJong EN, Surette MG, Bowdish DME.\nCell Host Microbe. 2020 Aug 12;28(2):180-189. doi: 10.1016\/j.chom.2020.07.013.\nPMID: 32791111\nReview. \n\n\n<\/td><\/tr>
    \n3. \n<\/td>\n\nSingle cell and tissue-transcriptomic analysis\n of murine bladders reveals age- and TNF\u03b1-dependent but microbiota-independent tertiary lymphoid tissue formation.\n<\/a>\n\nLigon MM, Wang C, DeJong EN, Schulz C, Bowdish DME, Mysorekar IU.\nMucosal Immunol. 2020 Nov;13(6):908-918. doi: 10.1038\/s41385-020-0290-x. Epub 2020 May 4.\nPMID: 32366865\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n4. \n<\/td>\n\nObesity during pregnancy results in maternal\n intestinal inflammation, placental hypoxia, and alters fetal glucose metabolism at mid-gestation.\n<\/a>\n\nWallace JG, Bellissimo CJ, Yeo E, Fei Xia Y, Petrik JJ, Surette MG, Bowdish DME, Sloboda DM.\nSci Rep. 2019 Nov 26;9(1):17621. doi: 10.1038\/s41598-019-54098-x.\nPMID: 31772245\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n5. \n<\/td>\n\nStarving the Gut: A Deficit of Butyrate in\n the Intestinal Ecosystem of Children With Intestinal Failure. <\/a>\n\nDowhaniuk JK, Szamosi J, Chorlton S, Owens J, Mileski H, Clause RF, Pernica JM, Bowdish DME, Surette MG, Ratcliffe EM.\nJPEN J Parenter Enteral Nutr. 2020 Aug;44(6):1112-1123. doi: 10.1002\/jpen.1715. Epub 2019 Oct 22.\nPMID: 31642067\n\n\n\n<\/td><\/tr>
    \n6. \n<\/td>\n\nLoss of Microbial Topography Precedes Infection\n in Infants. <\/a>\n\nSurette MG, Bowdish DME.\nAm J Respir Crit Care Med. 2019 Sep 15;200(6):660-662. doi: 10.1164\/rccm.201903-0687ED.\nPMID: 30978299\nFree PMC article.\nNo abstract available.\n\n\n\n<\/td><\/tr>
    \n7. \n<\/td>\n\nMicrobial dysbiosis and mortality during mechanical\n ventilation: a prospective observational study. <\/a>\n\nLamarche D, Johnstone J, \nZytaruk N, Clarke F, Hand L, Loukov D, Szamosi JC, Rossi L, Schenck LP, \nVerschoor CP, McDonald E, Meade MO, Marshall JC, Bowdish DME, Karachi T,\n Heels-Ansdell D, Cook DJ, Surette MG; PROSPECT\n Investigators; Canadian Critical Care Trials Group; Canadian Critical \nCare Translational Biology Group.\nRespir Res. 2018 Dec 7;19(1):245. doi: 10.1186\/s12931-018-0950-5.\nPMID: 30526610\nFree PMC article.\nClinical Trial.\n\n\n\n<\/td><\/tr>
    \n8. \n<\/td>\n\nCommensal microbiota induces colonic barrier\n structure and functions that contribute to homeostasis. <\/a>\n\nHayes CL, Dong J, Galipeau HJ, \nJury J, McCarville J, Huang X, Wang XY, Naidoo A, Anbazhagan AN, \nLibertucci J, Sheridan C, Dudeja PK, Bowdish DME, Surette MG, Verdu EF.\nSci Rep. 2018 Sep 21;8(1):14184. doi: 10.1038\/s41598-018-32366-6.\nPMID: 30242285\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n9. \n<\/td>\n\nStreptococcus pneumoniae Colonization Is Required\n To Alter the Nasal Microbiota in Cigarette Smoke-Exposed Mice. <\/a>\n\nShen P, Whelan FJ, Schenck LP, McGrath JJC, Vanderstocken G, Bowdish DME, Surette MG, St\u00e4mpfli MR.\nInfect Immun. 2017 Sep 20;85(10):e00434-17. doi: 10.1128\/IAI.00434-17. Print 2017 Oct.\nPMID: 28760931\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n10. \n<\/td>\n\nOn-going Mechanical Damage from Mastication\n Drives Homeostatic Th17 Cell Responses at the Oral Barrier. <\/a>\n\nDutzan N, Abusleme L, Bridgeman\n H, Greenwell-Wild T, Zangerle-Murray T, Fife ME, Bouladoux N, Linley H,\n Brenchley L, Wemyss K, Calderon G, Hong BY, Break TJ, Bowdish DME, \nLionakis MS, Jones SA, Trinchieri G, Diaz PI,\n Belkaid Y, Konkel JE, Moutsopoulos NM.\nImmunity. 2017 Jan 17;46(1):133-147. doi: 10.1016\/j.immuni.2016.12.010. Epub 2017 Jan 10.\nPMID: 28087239\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n11. \n<\/td>\n\nComposition and immunological significance\n of the upper respiratory tract microbiota. <\/a>\n\nSchenck LP, Surette MG, Bowdish DM.\nFEBS Lett. 2016 Nov;590(21):3705-3720. doi: 10.1002\/1873-3468.12455. Epub 2016 Nov 1.\nPMID: 27730630\nFree PMC article.\nReview. \n\n\n<\/td><\/tr>
    \n12. \n<\/td>\n\nStreptococcus pneumoniae Colonization Disrupts\n the Microbial Community within the Upper Respiratory Tract of Aging Mice. <\/a>\n\nThevaranjan N, Whelan FJ, Puchta A, Ashu E, Rossi L, Surette MG, Bowdish DM.\nInfect Immun. 2016 Mar 24;84(4):906-16. doi: 10.1128\/IAI.01275-15. Print 2016 Apr.\nPMID: 26787714\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n13. \n<\/td>\n\nCulture and molecular-based profiles show shifts\n in bacterial communities of the upper respiratory tract that occur with age. <\/a>\n\nStearns JC, Davidson CJ, McKeon S, Whelan FJ, Fontes ME, Schryvers AB, Bowdish DM, Kellner JD, Surette MG.\nISME J. 2015 May;9(5):1246-59. doi: 10.1038\/ismej.2014.250. Epub 2015 Jan 9.\nPMID: 25575312\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n14. \n<\/td>\n\nThe loss of topography in the microbial communities\n of the upper respiratory tract in the elderly. <\/a>\n\nWhelan FJ, Verschoor CP, Stearns JC, Rossi L, Luinstra K, Loeb M, Smieja M, Johnstone J, Surette MG, Bowdish DM.\nAnn Am Thorac Soc. 2014 May;11(4):513-21. doi: 10.1513\/AnnalsATS.201310-351OC.\nPMID: 24601676\n\n\n\n<\/td><\/tr>
    \n15. \n<\/td>\n\nThe impact of respiratory infections and probiotic\n use on the nasal microbiota of frail residents in long-term care homes. <\/a>\n\nBowdish DME, Rossi L, Loeb M, Johnstone J, Schenck LP, Fontes M, Surette MG, Whelan FJ.\nERJ Open Res. 2023 Sep 25;9(5):00212-2023. doi: 10.1183\/23120541.00212-2023. eCollection 2023 Sep.\nPMID: 37753289\nFree PMC article.\n\n\n\n<\/td><\/tr>
    \n16. \n<\/td>\n\nEffect of Probiotics on Incident Ventilator-Associated\n Pneumonia in Critically Ill Patients: A Randomized Clinical Trial. <\/a>\n\nJohnstone J, Meade M, Lauzier \nF, Marshall J, Duan E, Dionne J, Arabi YM, Heels-Ansdell D, Thabane L, \nLamarche D, Surette M, Zytaruk N, Mehta S, Dodek P, McIntyre L, English \nS, Rochwerg B, Karachi T, Henderson W, Wood\n G, Ovakim D, Herridge M, Granton J, Wilcox ME, Goffi A, Stelfox HT, \nNiven D, Muscedere J, Lamontagne F, D’Aragon F, St-Arnaud C, Ball I, \nNagpal D, Girard M, Aslanian P, Charbonney E, Williamson D, Sligl W, \nFriedrich J, Adhikari NK, Marquis F, Archambault P,\n Khwaja K, Kristof A, Kutsogiannis J, Zarychanski R, Paunovic B, Reeve \nB, Lellouche F, Hosek P, Tsang J, Binnie A, Trop S, Loubani O, Hall R, \nCirone R, Reynolds S, Lysecki P, Golan E, Cartin-Ceba R, Taylor R, Cook \nD; Prevention of Severe Pneumonia and Endotracheal\n Colonization Trial (PROSPECT) Investigators and the Canadian Critical \nCare Trials Group.\nJAMA. 2021 Sep 21;326(11):1024-1033. doi: 10.1001\/jama.2021.13355.\nPMID: 34546300\nFree PMC article.\nClinical Trial.\n\n\n<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"

    Project Description: Our immune system and the microbes that live on and in us change as we age, but whether these changes contribute to healthy\/unhealthy aging is not clear. We perform mechanistic experiments to understand whether age-related changes in the … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":3736,"parent":48,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3378","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/pages\/3378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/comments?post=3378"}],"version-history":[{"count":3,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/pages\/3378\/revisions"}],"predecessor-version":[{"id":3409,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/pages\/3378\/revisions\/3409"}],"up":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/pages\/48"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/media\/3736"}],"wp:attachment":[{"href":"https:\/\/www.bowdish.ca\/lab\/wp-json\/wp\/v2\/media?parent=3378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}